It is postulated that an uncontrolled increase of TNF-α production or sustained accumulation of TNF-α leads to detrimental effects on the myocardium. These effects include the induction of apoptosis, ...

Deficiency in apoptosis frequency at inflammation sites could be the cause of chronic inflammation verified in RA and CD patients. [12, 13] Studies mainly used the terminal deoxynucleotidyl ...

TNF-α is a potent inducer of the inflammatory response, a key regulator of innate immunity and plays an important role in the regulation of Th1 immune responses against intracellular bacteria and ...

It is well known that apoptosis is an actively mediated cell suicide process. In contrast, necrosis, a morphologically distinct form of cell death, has traditionally been regarded as passive and ...

Review Article Published: December 2006 Mechanisms of Disease: apoptosis in heart failure—seeing hope in death Jagat Narula, Nezam Haider, Eloisa Arbustini & Y Chandrashekhar Nature Clinical ...

Objective To assess the effects of treatment with antitumour necrosis factor (TNF) agents, methotrexate, or other non-biological disease-modifying antirheumatic drugs (DMARDs) on cardiovascular event ...

Recombinant proteins are critical for modern therapeutics and diagnostics, with Chinese hamster ovary (CHO) cells serving as the primary production platform. However, environmental and chemical ...

Accurate and real-time monitoring of biomarker proteins, such as Tumor Necrosis Factor (TNF) alpha, plays a vital role in early disease diagnosis, effective treatment design, and personalized health ...

Therefore, TNF-α (1) modulates cell growth, differentiation and metabolism; (2) leads to cachexia by inhibiting stimulation of liver lipogenesis and stimulating lypolysis (3) initiates apoptosis of ...