Methods:: In this study, α-MMC was extracted from momordica charantia seeds, and a series of in vitro studies were carried out on lung cancer A549 and 95-D cells, such as cell proliferation, cycle, ...

Therefore, TNF-α (1) modulates cell growth, differentiation and metabolism; (2) leads to cachexia by inhibiting stimulation of liver lipogenesis and stimulating lypolysis (3) initiates apoptosis of ...

CD95-L, TNF-α and TRAIL are death-inducing ligands (DILs) which may signal apoptosis via crosslinking of their cognate receptors. The present study shows that treatment of cells with agonistic ...

Deficiency in apoptosis frequency at inflammation sites could be the cause of chronic inflammation verified in RA and CD patients. [12, 13] Studies mainly used the terminal deoxynucleotidyl ...

It is well known that apoptosis is an actively mediated cell suicide process. In contrast, necrosis, a morphologically distinct form of cell death, has traditionally been regarded as passive and ...

TNF-α is a potent inducer of the inflammatory response, a key regulator of innate immunity and plays an important role in the regulation of Th1 immune responses against intracellular bacteria and ...

Background Chronic inflammation and elevated reactive oxygen species are key contributors to hepatocellular carcinoma (HCC) ...

Review Article Published: December 2006 Mechanisms of Disease: apoptosis in heart failure—seeing hope in death Jagat Narula, Nezam Haider, Eloisa Arbustini & Y Chandrashekhar Nature Clinical ...

Accurate and real-time monitoring of biomarker proteins, such as Tumor Necrosis Factor (TNF) alpha, plays a vital role in early disease diagnosis, effective treatment design, and personalized health ...

Recombinant proteins are critical for modern therapeutics and diagnostics, with Chinese hamster ovary (CHO) cells serving as the primary production platform. However, environmental and chemical ...

It is postulated that an uncontrolled increase of TNF-α production or sustained accumulation of TNF-α leads to detrimental effects on the myocardium. These effects include the induction of apoptosis, ...

Objectives To investigate whether tumour necrosis factor alpha inhibitors (TNFis) are associated with an increased risk of neuroinflammatory diseases among patients with arthritic diseases. Methods ...