A new study reveals how restoring α-synuclein levels can help preserve synaptic vesicle composition and function, offering ...

This explainer outlines how neurons and glial cells coordinate electrical and chemical signals to form complex brain networks ...

For example, the researchers showed that in physiological conditions, local variations in ATP can also affect the viscosity of the cytosol, of synaptic vesicles and of active zones in the ...

While a comprehensive cure-all to these neurological conditions is unlikely, scientists are making headway into understanding their fundamental characteristics with the hope of preventing or ...

ATP has been found to regulate cytosolic viscosity and thereby protein aggregation, which can lead to synaptic dysfunction and neurodegeneration. NMN (nicotinamide mononucleotide) is a precursor ...

In recent years, the 1954 Serotonin Theory of Depression and SSRIs have been thoroughly investigated by scientific ...

The substantial volume of these compartments, estimated to contain ∼2500-5000 vesicles in the SFL presynaptic area, suggests a high reliability in synaptic transmission within this zone. In the second ...

Next, we evaluated excitatory synaptic transmission through whole-cell patch-clamp ... However, β-CTF localizes within the intracellular membrane of endo/lysosomal vesicles, rendering it inaccessible ...