Hence, IL-23 is less systemic and more tissue specific than TNF inhibitors.” This translates into efficacy without the same risk for infections as TNF blockers, according to Hanauer.

One instance pertains to the black box warning for lymphoma in patients treated with TNF inhibitors. Although some of the pre-approval studies demonstrated significant risk, others did not.

Cite this: TNF Signaling Inhibition in the CNS: Implications for Normal Brain Function and Neurodegenerative Disease - Medscape - Oct 17, 2008.

Humira belongs to a group of drugs called tumor necrosis factor inhibitors, which help reduce inflammation in the body. If you have a certain type of arthritis or a disease related to inflammation ...

Patrick Aiyes, senior immunology analyst at GlobalData, notes that the immunology market has seen a continuous increase in the sales of interleukin inhibitors and a decrease in the sales of TNF ...

Angiotensin-converting enzyme (ACE) inhibitors or angiotensin-receptor blockers (ARBs) are recommended widely as first-line treatments for hypertension in patients with diabetic or nondiabetic ...

The drug performed better than placebo on clinical, symptomatic, endoscopic and histologic endpoints regardless of previous failure to TNF inhibitors, other biologic therapies or Pfizer's JAK ...

Reporting in ACR Open Rheumatology, Zavoriti and Miossec provide data that might explain the prothrombotic effects of the JAK inhibitor tofacitinib. Modifications enhancing degradation resistance ...

FAP inhibitor (FAPI) radiopharmaceuticals are considered to be the most promising to be developed for targeting FAP due to their rapid and specific tumor targeting. This review briefly outlines the ...

Equus How did horses become some of the greatest athletes in the animal kingdom? Researchers at Johns Hopkins Medicine have pinpointed a genetic mutation and evolutionary process that occurred ...

Patients receiving treatment with either IS drugs (cyclosporine A, methotrexate) or systemic corticosteroids during anti-TNF therapy or within 3 weeks before the beginning of the therapy were also ...