without changing its overall shape via non-covalent means. Unlike traditional chirality that originates from covalent bonds forming asymmetric centers, in MIMs the chirality can arise from the way ...

FMC-220 is designed to address the potency and durability challenges seen with non-covalent approaches targeting the structurally destabilized p53 Y220C mutant. Preclinical studies showed FMC-220 ...

During a live event, Shuo Ma, MD, PhD, discussed the outcomes of the BRUIN trial of pirtobrutinib in BTK inhibitor–pretreated ...

To fix this, the MIT researchers developed a new ultra-thin material that can sense infrared radiation without any cooling ...

non-covalent bonds. Valsartan is an angiotensin receptor blocker (“ARB”) that prevents angiotensin II from binding to its receptor, thereby reducing the blood-vessel-constricting effects of ...

Although textbooks on the physics of condensed matter consider non-covalent interactions in detail, their application for analysis of protein properties is often poorly presented or omitted. On the ...

Traditional non-covalent ligands like thiazolininediones (TZDs) show clinical benefit in metabolic diseases, but utility is limited by off-target effects and transient receptor engagement. In previous ...

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