Thomas S. Kuhn The Structure Of Scientific Revolutions by Thomas S kuhn Publication date 1990 Usage Public Domain Mark 1.0 Topics Science Collection folkscanomy_philosophy; folkscanomy; ...

All are secreted proteins except the single CX3C chemokine, CX3CL1 (fractalkine), in which the chemokine domain is followed by a mucin-type stalk, a transmembrane domain and a cytoplasmic tail 5, 6.

CXCL12 is a human chemokine that recognizes the CXCR4 receptor and is involved in immune responses and metastatic cancer. Interactions between CXCL12 and CXCR4 are an important drug target but, like ...

In the absence of an experimentally determined binding mode for the cyclopentapeptide CXCR4 antagonists, we have rationally designed conformationally constrained analogues to further probe the small ...