Read before the Philadelphia County Medical Society, October 17, 1883. Physician to the Philadelphia Hospital for Skin Diseases, Lecturer and Instructor on Diseases of the Skin in the Summer ...

How neoadjuvant immunotherapy compares with standard adjuvant immunotherapy in patients with resectable, macroscopic stage III melanoma has been unclear. New research findings are summarized in a ...

This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when ...

Medication abortion, with a combination of mifepristone and misoprostol, is highly effective and safe. However, there is insufficient evidence on efficacy and safety at very early gestations ...

In this Journal feature, information about a real patient is presented in stages (boldface type) to an expert clinician, who responds to the information by sharing relevant background and ...

A tool used by the government for substance-use surveillance has consistently reported low rates of OUD. But the survey excluded a large group of Americans with OUD: people who take opioids as ...

Epidural glucocorticoid injection is an intervention commonly used for managing lumbosacral radicular pain. The goal of the injection is to administer glucocorticoids to the epidural space to ...

In patients with out-of-hospital cardiac arrest, the effectiveness of drugs such as epinephrine is highly time-dependent. An intraosseous route of drug administration may enable more rapid drug ...

Weight reduction has been shown to alleviate symptoms of osteoarthritis of the knee, including pain. The effect of glucagon-like peptide-1 receptor agonists on outcomes in knee osteoarthritis ...

Severe tricuspid regurgitation is associated with disabling symptoms and an increased risk of death. Data regarding outcomes after percutaneous transcatheter tricuspid-valve replacement are needed.

Although lead has been mined for 6000 years, lead processing skyrocketed in the 20th century. 1,8 A malleable and durable metal, lead was used to prevent fuel from burning too quickly and to ...

Supported by grants (U01DK072493 and UM1 DK072493, to Dr. Inge, and UM1 DK095710, to Drs. Jenkins and Xie) from the National Institutes of Health (NIH) and grants (UL1TR000077 and UL1TR000114 ...