A new study reveals how restoring α-synuclein levels can help preserve synaptic vesicle composition and function, offering ...

This explainer outlines how neurons and glial cells coordinate electrical and chemical signals to form complex brain networks ...

Cellular communication is a critical process that relies on exocytosis, during which cells release stored chemical messengers contained within intracellular nanoscale vesicles (50–500 nm in diameter).

Buchmann Institute for Molecular Life Sciences, Goethe-University, Frankfurt am Main, Germany Institute for Biophysical Chemistry, Department of Biochemistry, Chemistry, and Pharmacy, ...

Engineered extracellular vesicles incorporating a viral fusogenic protein and bacterial intein enable efficient intracellular delivery of therapeutic proteins and RNA.

International PhD Program in Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Shuang-Ho Campus, New Taipei City 110, Taiwan International PhD Program in Biomedical ...

Here, we describe the isolation and structure determination of proteins in membrane vesicles derived directly from cells. Structures of the ion channel Slo1 from total cell membranes and from cell ...

ATP has been found to regulate cytosolic viscosity and thereby protein aggregation, which can lead to synaptic dysfunction and neurodegeneration. NMN (nicotinamide mononucleotide) is a precursor ...

Aβ is believed to play a significant role in synaptic degeneration observed in Alzheimer’s disease and is primarily investigated as a secreted peptide. However, the contribution of intracellular Aβ or ...