During a live event, Shuo Ma, MD, PhD, discussed the outcomes of the BRUIN trial of pirtobrutinib in BTK inhibitor–pretreated ...

without changing its overall shape via non-covalent means. Unlike traditional chirality that originates from covalent bonds forming asymmetric centers, in MIMs the chirality can arise from the way ...

FMC-220 is designed to address the potency and durability challenges seen with non-covalent approaches targeting the structurally destabilized p53 Y220C mutant. Preclinical studies showed FMC-220 ...

Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P.R. China University of Chinese Academy of ...

Covalent drugs form permanent bonds with target proteins, which makes them longer-lasting and potentially more potent than non-covalent drugs. Some, like aspirin and penicillin, have been around ...