During a live event, Shuo Ma, MD, PhD, discussed the outcomes of the BRUIN trial of pirtobrutinib in BTK inhibitor–pretreated ...

Non-salt drugs are also termed free acids or free bases; non-salt drugs have covalent and other non-ionic bonds. For compounding purposes, the active moiety of a non-salt drug comprises the entire ...

Covalent drugs form permanent bonds with target proteins, which makes them longer-lasting and potentially more potent than non-covalent drugs. Some, like aspirin and penicillin, have been around ...

To fix this, the MIT researchers developed a new ultra-thin material that can sense infrared radiation without any cooling ...

Although textbooks on the physics of condensed matter consider non-covalent interactions in detail, their application for analysis of protein properties is often poorly presented or omitted. On the ...

non-covalent bonds. Valsartan is an angiotensin receptor blocker (“ARB”) that prevents angiotensin II from binding to its receptor, thereby reducing the blood-vessel-constricting effects of ...

Traditional non-covalent ligands like thiazolininediones (TZDs) show clinical benefit in metabolic diseases, but utility is limited by off-target effects and transient receptor engagement. In previous ...

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