The crystal structure of CCR2 chemokine receptor in a complex with two different antagonists—one orthosteric the other allosteric—which functionally cooperate to inhibit CCR2. Chemokine ...

The most common chemokine structure is the characteristic Greek key shape, which is formed by the interaction of two pairs of cysteines, with an intramolecular disulfide bond joining the first and ...

They also share a similar structure and contain cysteine residues that determine their three dimensional shape. Chemokines bind to chemokine receptors, which are part of the family of G protein ...

Chemokine receptors, located at the surface of many immune cells, play an important role in their function. Chemokines are small proteins that bind to these receptors and control the movement and ...

Chemokine receptors, located at the surface of many immune cells, play an important role in their function. However, despite the importance of this family of receptors, their activation mechanism ...

A major role of chemokines is to mediate leukocyte migration through interaction with G-protein-coupled receptors. Various delivery systems have been developed to utilize the chemokine properties ...

Background: Proinflammatory chemokines/cytokines support development and maturation of tertiary lymphoid structures (TLS) within the tumor immune microenvironment (TIME). In the current study, we ...

The approximately 50 human chemokines segregate into four families on the basis of differences in structure and function (Table 1 and Table 2). 1–5 A systematic nomenclature has been adopted in ...

The right key to fit in the lock. The receptor, which is embedded in the cell membrane, works like a “lock and key” mechanism. A specific part of the chemokine structure must fit into the CCR5 lock to ...

Dubinett et al. explained a functional 'lymph node-like' structure creation by genetically modified CCL21-producing melanoma lysate-pulsed DCs. ... Coadministration of chemokine with antigen: ...