Furthermore, at lowered concentrations, which did not directly induce apoptosis, SI-27 acted to sensitize U937 cells and other cells to tumor necrosis factor α (TNF-α)-mediated apoptosis.

Anti-TNF-α Agents in the Treatment of Immune-mediated Inflammatory Diseases: Mechanisms of Action and Pitfalls. ... Apoptosis. Apoptosis, or programmed cell death, ...

The main extrinsic mediator of apoptosis is TNF-alpha, a cytokine that is produced by activated macrophages. The cytokine binds to the TNFR1 and TNFR2 receptors, which are present in most human cells.

Second, in TNF-activated endothelial cells, NGR-TNF inhibits Mek, Erk1/2, and Akt, and activates caspases 3, 8, and 9, resulting in tumor endothelial cells apoptosis in vivo. Of note, these pathways ...

Discussion This study shows that SP, through stimulation of the NK-1 R, has the ability to reduce TNF-α-induced apoptosis of human tenocytes. Considering that SP has previously been shown to stimulate ...

September 7, 2011 (UPDATED September 25, 2011) — The boxed warning on the labels of all tumor necrosis factor alpha (TNF-alpha) inhibitors will be updated to warn about the risk for serious, and ...

Prognostic Significance of Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand and Its Receptors in Adjuvantly Treated Stage III Colon Cancer Patients. JCO 24 , 4998-5004 (2006). DOI: ...

BALTIMORE, March 17, 2025--TNF Pharmaceuticals, Inc. (Nasdaq: TNFA) ("TNF" or the "Company"), a clinical stage biopharmaceutical company committed to developing novel therapies for autoimmune and ...

BALTIMORE, February 25, 2025--TNF Pharmaceuticals, Inc. (Nasdaq: TNFA) ("TNF" or the "Company"), a clinical stage biopharmaceutical company committed to developing novel therapies for autoimmune ...

Tofacitinib (formerly known as tasocitinib or CP-690550) and fostamatinib disodium will likely be used ahead of the TNF-alpha inhibitors and will therefore divert a minority of patients away from ...