helped us understand the mechanisms by which these genes control apoptosis. The structure of CD95 suggested that it belonged to the tumour necrosis factor (TNF) receptor family and that there ...

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) selectively induces apoptosis of tumor cells but not most normal cells. Its roles in normal nontransformed tissues are not clear.

55 11 3061 7457 Fax: +55 11 3081 7190 [email protected] Establishing that TNF-α plays an important role ... thus reducing cell recruitment; apoptosis of monocytes and T cells; changes in the immune ...