The replication fork is more than just a means for DNA duplication. It is connected to a checkpoint system that keeps the genome intact and prevents cancer.

The replication fork is more than just a means for DNA duplication. It is connected to a checkpoint system that keeps the genome intact and prevents cancer. Aa Aa Aa Eukaryotic genomes are ...

Scientists at the University of Iowa have made an exciting discovery that could lead to new cancer-fighting drugs. They found ...

Emerging evidence suggests that a variety of environmental factors and toxins damage DNA, leading to an arrest of the DNA replication fork, the actual site of DNA synthesis. Arrested replication forks ...

To obtain this image, the team created a DNA substrate resembling a stalled DNA replication fork. The substrate fixes the RAD52 complex in place by bringing the two rings together with all three ...

Research in my laboratory centers on: (i) the events that occur when the replisome (the multi-component enzyme machine that replicates chromosomal DNA) encounters blockages to replication fork ...

Figure 1: Mechanism of DNA replication in eukaryotes. A large multi-subunit protein complex, called replisome, coordinates DNA unwinding with DNA synthesis at the fork. Over 20 distinct proteins and ...

To obtain this image, the team created a DNA substrate, which resembles a stalled DNA replication fork. The substrate fixes the RAD52 complex in place by bringing the two rings together with all ...