Indomethacin ER capsule, 75mg twice a day can be substituted for indomethacin immediate-release capsule 50mg three times a day. The following is the Adult Dose for Indomethacin immediate-release ...

Indomethacin has analgesic ... If well tolerated, may increase the daily dose by 25 or 50mg at weekly intervals (if required by continued symptoms) until a satisfactory response is obtained ...