Erythema migrans and erythema multiforme both cause target- or bull’s-eye-shaped lesions. Erythema migrans is due to Lyme disease. Erythema multiforme is an immune-mediated hypersensitivity skin ...

Erythema multiforme is an immune-mediated reaction that causes a raised, red, target-like rash on the skin or mucous membranes. It often resolves on its own but may require medical treatment.