In Canada, "the average lifespan of someone with Down syndrome is about 60 years old," said Dr. Brian Skotko, senior author ...

People with Down syndrome have a unique genetic predisposition: overexpression of the APP gene due to trisomy of chromosome 21 leads to overproduction of beta-amyloid (Aβ) protein, making them a ...

A new research paper, featured on the cover of Aging (Aging-US) Volume 17, Issue 6, was published on June 4, 2025, titled “DoliClock: a lipid-based aging clock reveals accelerated aging in ...

The research team evaluated brain tissue samples from 15 people with Down syndrome who were between the ages of 43 and 68 years. The study was limited in its sample size and age range - in the ...