Chromatin structure has a large impact on DNA replication and repair programs. During DNA replication, cells need to disassemble nucleosomes ahead of the replication fork and reassemble them ...

to show that RAD52 proteins form an unexpected spool-like structure composed of two rings of RAD52, each containing 11 copies of protein, that engages all three arms of the "DNA replication fork ...

In the folded fork structure shown in the inset ... other proteins (not shown) are needed for DNA replication. These include a set of initiator proteins to begin each new replication fork at ...

Double ring structure protects DNA Spies and Pichierri had previously discovered that RAD52 is important in protecting stalled DNA replication forks. Their work suggested that this new function of ...

However, the process of DNA replication intrinsically disrupts nucleosomes ahead of the fork raising the question how chromatin structure is maintained across generations. Nucleosomes are re-assembled ...

to show that RAD52 proteins form an unexpected spool-like structure composed of two rings of RAD52, each containing 11 copies of protein, that engages all three arms of the "DNA replication fork ...

Our lab showed that an analogous cohesion process occurs in bacteria, in which replicated DNA is linked together as it exits the replication fork, remaining stably attached ... sister chromosomes in a ...