The process of transcription elongation by RNA polymerase II (Pol II), in which Pol II travels along DNA and synthesizes RNA from DNA, is essential for proper gene expression in all eukaryotic cells.

RNA polymerase II phosphorylation regulates a switch between transcriptional ... Architecture of the human and yeast general transcription and DNA repair factor TFIIH. Mol Cell 2015, 59: 794 – 806.

Biology lectures teach students that when a cell’s replication machinery comes together, DNA polymerase takes off down the double-helix like a car on a highway ...

Invitrogen™ Platinum™ SuperFi II DNA Polymerase is a hot-start, engineered proofreading DNA polymerase, providing superior fidelity and specificity to your PCR. With >300x Taq fidelity and buffer ...

Thus, it is RNA pol II that transcribes the messenger ... Once transcription is initiated, the DNA double helix unwinds and RNA polymerase reads the template strand, adding nucleotides to the ...

Single-Molecule Footprinting reveals that RNA polymerase II (Pol II) occupancy is infrequent at mouse promoters. This results ...

Forensic DNA profiling uses polymerase chain reaction (PCR) to amplify short tandem repeats (STRs), which are highly variable DNA regions, typically with four repeating bases. This variability helps ...

Enzymes called RNA polymerases transcribe DNA into RNA. RNA is the intermediary that carries ... of RNA polymerases that can transcribe different types of RNA. RNA polymerase II, shown here, is ...

This polymerase contains four catalytic subunits ... For example, researchers know that RNA pol II can bind to a DNA sequence within the promoter of many genes, known as the TATA box, to initiate ...

Poly-ADP ribose polymerase (PARP) inhibition previously was shown to be particularly effective in cancers harboring gene mutations that negatively affect DNA repair, such as BRCA1/2 mutations ...