The common gamma-chain cytokines signal through cytokine receptors that consist of the common cytokine receptor γ chain (γc/CD132/IL2RG). This family includes at least six short-chain cytokines: IL2, ...

Researchers analyzed a library of engineered receptors derived from natural cytokine receptors, focusing on Modular ...

Upon binding to their surface receptors, cytokines trigger downstream signaling cascades associated with many cellular processes, such as differentiation, tissue repair, proliferation, migration, and ...

Cytokine bioactivity can be regulated at the levels of transcription, translation, cleavage and cellular release, as well as through receptor and post-receptor signalling mechanisms. The activity ...

Signaling by type I cytokines involves the formation of receptor homodimers, heterodimers or higher order receptor oligomers. Here we report the cloning of a type I cytokine receptor subunit that ...

IL17 is part of a cytokine family that includes five other members: IL17B, IL17C, IL17D, IL17E/IL25 and IL17F. The sequences of IL17 and IL17F are the most similar. To signal through the receptor ...

Toll-like receptor 4 activation consequently produces an innate immune response in the brain that initiates the release of glial-derived neuroexcitatory and neurotoxic substances such as ...

Siltuximab effectively treated patients who experienced common adverse events after chimeric antigen receptor T-cell therapy, ...