Global understanding of complement has shifted and developed since the 21st century: from our idea of a blood-based antibiotic system to a global regulator of immunity and tissue homeostasis. Recent ...

Dysregulation of the complement cascade is implicated in the pathogenesis of several inflammatory and allergic disorders, such as arthritis, ischaemia–reperfusion injury and asthma. In a study ...

In a recent study posted to the bioRxiv* pre-print server, researchers investigated the complement component 1q (C1q) binding and subsequent complement activation by neutralizing antibodies (nAbs) ...

Activation of the complement cascade of proteases has been linked to autoimmune and kidney diseases, including systemic lupus ...

Most people are familiar with the immune system and its role in protecting against diseases and infection. But what about the complement system? The complement system is a foundational part of the ...

VALLEY COTTAGE, N.Y. – Complement system consists of more than 30 proteins and it operates as defense against infection. Composition of the 30 proteins in blood or serum is known as complement cascade ...

Kupffer cells and other macrophage cell types help clear complement-coated pathogens. As part of the innate immune system, elements of the complement cascade can be found in species earlier than ...

In view of the importance of complement system in the initiation, regulation and end effects of immune responses and understanding of immune system as one of the targets for the toxic effects of ...

Last year, four independent research groups reported a linkage between polymorphisms in the complement factor H (CFH) gene to age-related macular degeneration (AMD), the most common cause of blindness ...