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Optimizing differentiation protocols and experimental assays to study patient-specific astrocytes
Therefore, the researchers determined whether iPSC-derived astrocytes are responsive to inflammatory stimuli such as tumor necrosis factor-alpha (TNF-α) and interleukin 1-beta (IL-1β).
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TNF-alpha Modulation for Treatment of Alzheimer's Disease: A 6-Month Pilot Study
Tumor necrosis factor (TNF)-alpha, a proinflammatory cytokine, has been implicated in the pathogenesis of AD. Objective: To investigate the use of a biologic TNF-alpha inhibitor, etanercept was ...